Pharmacology

Questions:
Background
Every day research is carried out in pharmaceutical organizations, university, institute and hospital laboratories looking for new and better treatments for diseases. We want you to focus on a new or a potential new target (ie identified in the last ten years) for a disorder, for example, an enzyme or a receptor or other proteins that have recently been identified as novel targets for new drug development for the disorder you choose. You may choose to begin by identifying a drug that has recently come onto the market and then focus on the target of that drug or you may identify a novel target for which drugs are still in the development phase. PLEASE ENSURE YOU FAMILIARISE YOURSELF WITH THE CRITERIA AND FEATURES OF THE ASSIGNMENT.

Task Instructions
A list of disorders has been provided for you, please select one of interest. Information MUST come
from published, peer-reviewed scientific papers.

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Features of the assignment
The principal features of the assignment should be completed in your own words:
1. Briefly Introduce what will be covered in the essay

2.Description of disorder. Describe the disease/condition you have chosen

3.Current therapies. Describe the current treatments for the disease/condition

4.New target. (remember to explain in your own words!!)

5. Describe the new target that has been identified

6. The role the target plays in normal physiology

7. Critically appraise the evidence in the research literature that has investigated the role of the target in the disease/condition (the evidence should be preclinical (laboratory work) and clinical where available)

8. Briefly conclude your essay by highlighting the key points

9.Your Response must be typed (Times New Roman, 12 point) with 1.5 spacing and margins of 2.5 cm. It is to be 800 (± 5%) words (not including references). Indicate the word count in your essay.

10.Include a Title, your name and student number and page numbers.

References
References should be included
Only two of these references should be review articles, the rest should be original articles that contain the original scientific data
References should be cited in the text as indicated below, and presented in the reference list in the format shown and it should be appear at the end on the essay under the title references.
Please note the examples below
Websites should not be used except from incidence data, and if used, they must be reputable sites.
Reference Style. Be consistent and use Harvard Referencing Forma
Websites CANNOT be used APART from epidemiological data etc.

The principal features of the assignment should be completed in your own words. You will be assessed on your ability to:
1. Briefly Introduce what will be covered in the essay
2.Description of disorder. Describe the disease/condition you have chosen
3.Current therapies. Describe the current treatments for the disease/condition
4.New target. (remember to explain in your own words!!)
5. Describe the new target that has been identified
6. The role the target plays in normal physiology
7. Critically appraise the evidence in the research literature that has investigated the role of the target in the disease/condition (the evidence should be preclinical (laboratory work) and clinical where available)
8. Briefly conclude your essay by highlighting the key points

Topics:
New therapeutic targets for:
Organ transplantation Macular degeneration Hepatitis Ebola virus Huntington’s Disease Cancer eg lung, endometrial, prostate, breast
Post-traumatic stress disorder Inflammatory Diseases eg Psoriasis, Rheumatoid Arthritis Parkinson’s Disease Alzheimer’s disease
Amyotrophic lateral sclerosis Duchenne muscular dystrophy Multiple sclerosis